Publications de l'équipe 8

Sélection de publications


  • Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study. Joguet G, Mansuy JM, Matusali G, Hamdi S, Walschaerts M, Pavili L, Guyomard S, Prisant N, Lamarre P, Dejucq-Rainsford N, Pasquier C, Bujan L. Lancet Infect Dis.
  • Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants. Gaudriault P, Mazaud-Guittot S, Lavoué V, Coiffec I, Lesné L, Dejucq-Rainsford N, Scholze M, Kortenkamp A, Jégou B. Environ Health Perspect.
  • Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis. Desdoits-Lethimonier C, Lesné L, Gaudriault P, Zalko D, Antignac JP, Deceuninck Y, Platel C, Dejucq-Rainsford N, Mazaud-Guittot S, Jégou B. Hum Reprod.
  • Ibuprofen results in alterations of human fetal testis development. Ben Maamar M, Lesné L, Hennig K, Desdoits-Lethimonier C, Kilcoyne KR, Coiffec I, Rolland AD, Chevrier C, Kristensen DM, Lavoué V, Antignac JP, Le Bizec B, Dejucq-Rainsford N, Mitchell RT, Mazaud-Guittot S, Jégou B. Sci Rep.
  • Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry. Jégou B, Sankararaman S, Rolland AD, Reich D, Chalmel F. Mol Biol Evol.


  • Comparison of the effect of semen from HIV-infected and uninfected men on CD4+T cell infection. Camus C, Matusali G., Bourry O., Mahé D., Aubry F., Bujan L., Pasquier C., Massip P., Ravel C., Zirafi O., Munch J., Roan N.R., Pineau C., Dejucq-Rainsford N. AIDS
  • Analgesic use – prevalence, biomonitoring and endocrine and reproductive effects. Kristensen DM, Mazaud-Guittot S, Gaudriault P, Lesné L, Serrano T, Main KM, Jégou B. Nat Rev Endocrinol
  • Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility. Holm JB, Mazaud-Guittot S, Danneskiold-Samsøe NB, Chalmey C, Jensen B, Nørregård MM, Hansen CH, Styrishave B, Svingen T, Vinggaard AM, Koch HM, Bowles J, Koopman P, Jégou B, Kristiansen K, Kristensen DM. Toxicol Sci.
  • Array-CGH diagnosis in ovarian failure: identification of new molecular actors for ovarian physiology. Jaillard S, Akloul L, Beaumont M, Hamdi-Roze H, Dubourg C, Odent S, Duros S, Dejucq-Rainsford N, Belaud-Rotureau MA, Ravel C.  J Ovarian Res.
  • PepPSy: a web server to prioritize gene products in experimental and biocuration workflows.Sallou O, Duek PD, Darde TA, Collin O, Lane L, Chalmel F. Database (Oxford).



  • Acetaminophen-induced endocrine disruption in the human fetal testis and cryptorchidism. Jégou B. Nature Rev Endocrinol
  • The ReproGenomics Viewer: an integrative cross-species toolbox for the reproductive science community. Darde TA, Sallou O, Becker E, Evrard B, Monjeaud C, Le Bras Y, Jégou B, Collin O, Rolland AD, Chalmel F. Nucleic Acids Res.
  • Adipose tissue is a neglected viral reservoir and an inflammatory site during chronic HIV and SIV infection. Damouche A, Lazure T, Huot N, Dejucq-Rainsford N, Avettand-Fénoël V, Satie AP, Mélard A, David L, Gommet C, Ghosn J, Noel N, Pourcher G, Martinez V, Benoist S, Beréziat V, Cosma A, Favier B, Vaslin B, Rouzioux C, Capeau J, Müller-Trutwin M, Dereuddre-Bosquet N, Le Grand R, Lambotte O and Bourgeois C. PLOS Pathogens.
  • Detection of SIV in semen, urethra and male reproductive organs during efficient HAART. Matusali G., Dereuddre-Bosquet N., Le Tortorec A., Moreau M., Satie A-P., Mahé D., Roumaud P., Bourry O., Sylla N., Bernard-Stoecklin S., Pruvost A., Le Grand R., Dejucq-Rainsford N. Journal of Virology
  • Aniline is rapidly converted into paracetamol impairing male reproductive development. Holm JB, Chalmey C, Modick H, Jensen LS, Dierkes G, Weiss T, Jensen B, Nørregård MM, Borkowski K, Styrishave B, Koch HM, Mazaud-Guittot S, Jegou B, Kristiansen K, Kristensen DM. Aniline is rapidly converted into paracetamol impairing male reproductive development. Toxicol Sci. 
  • A New Method for Rapid Screening of End-point PCR Products: Application to Single Genome Amplified HIV and SIV Envelope Amplicons.Houzet L., Deleage C., Satie A-P, Merlande L., Mahé D., Dejucq-Rainsford N.  PLoS One.
  • An investigation of the endocrine-disruptive effects of Bisphenol A in human and rat fetal testes. Ben Maamar M, Lesné L, Desdoits-Lethimonier C, Coiffec I, Lassurguère J, Lavoué V, Deceuninck Y, Antignac, JP, Le Bizec B, Perdu E, Zalco D, Pineau C, Chevrier C, Dejucq-Rainsford N, Mazaud-Guittot S and Jégou B.  PLoS One.
  • Combining RNA and Protein Profiling Data with Network Interactions Identifies Genes associated with Spermatogenesis in Mouse and Human. Petit FG, Kervarrec C, Jamin SP, Smagulova F, Hao C, Becker E, Jégou B, Chalmel F, Primig M. . Biol Reprod. 
  • Linking transcriptomics and proteomics in spermatogenesis. Chalmel F and Rolland AD.  Reproduction.


  • Allograft evolution after kidney transplantation in HIV-1 infected patients. CanaudG, Dejucq-Rainsford N, Avettand-Fenoël V, Anglicheau D, Bienaimé F, Muorah M, Galmiche L, Gribouval O, Noël L-H, Satie A-P, Muda A.O, Gubler M-C, Friedlander G, Antignac C, Terzi F, Rouzioux C, Legendre C. Journal of the American Society of Nephrology,
  • Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling. Callier P, Calvel P, Matevossian A, Makrythanasis P, Bernard P, Kurosaka H, Vannier A, Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M, Zimmermann C, Stévant I, Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jaruzelska J, Faivre L, Wilhelm D, Jégou B, Trainor PA, Resh MD, Antonarakis SE, Nef S. PLoS Genet.
  • Origins of HIV-infected leukocytes and virions in semen. Houzet L, Matusali G, Dejucq-Rainsford N. Journal of Infectious Diseases.
  • The dynamic transcriptional profile of Sertoli cells during the progression of spermatogenesis. Zimmermann C, Stévant I, Borel C, Conne B, Pitetti JL, Calvel P, Kaessmann H, Jégou B, Chalmel F*, Nef S*.  Mol Endocrinol.
  • Pre- and postnatal exposure to low dose glufosinate ammonium induces autism-like phenotypes in mice. Laugeray A, Herzine A, Perche O, Hébert B, Aguillon-Naury M, Richard O, Menuet A, Mazaud-Guittot S, Lesné L, Briault S, Jégou B, Pichon J, Montécot-Dubourg C, Mortaud S. Front Behav Neurosci.
  • Systemic compensatory response to neonatal estradiol exposure does not prevent depletion of the oocyte pool in the rat. Chalmey C, Giton F, Chalmel F, Fiet J, Jégou B, Mazaud-Guittot S.  PLoS One.
  • Forty-four novel protein-coding loci discovered using a proteomics informed by transcriptomics (PIT) approach in rat male germ cells. Chocu S, Evrard B, Lavigne R, Rolland AD, Aubry F, Jégou B, Chalmel F, Pineau C.  Biol Reprod.
  • High-resolution profiling of novel transcribed regions during rat spermatogenesis. Chalmel F, Lardenois A, Evrard B, Rolland AD, Sallou O, Dumargne MC, Coiffec I, Collin O, Primig M, Jégou B. Biol Reprod.
  • GATA4 autoregulates its own expression in mouse gonadal cells via its distal 1b promoter. Mazaud-Guittot S, Prud’homme B, Bouchard MF, Bergeron F, Daems C, Tevosian SG, Viger RS. Biol Reprod


  • A critical assessment of the endocrine susceptibility of the human testis to phthalates from fetal life to adulthood. Albert O, Jégou B.  Hum Reprod Update.
  • Semen CD4+ T cells and macrophages are productively infected at all stages of SIV infection in macaques. Bernard-Stoecklin S, Corneau A, Dejucq-Rainsford N, Cosma A, Dereuddre-Bosquet N, Le Grand R. PLoS Pathogens.
  • Paracetamol, aspirin and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent. Mazaud-Guittot S, Nicolaz CN, Desdoits-Lethimonier C, Coiffec I, Ben Maamar M, Balaguer P, Kristensen DM, Chevrier C, Lavoué V, Poulain P, Dejucq-Rainsford N, Jégou B. J Clin Endocrinol Metab.
  • Paracetamol, aspirin and indomethacin display endocrine disrupting properties in the adult human testis in vitro. Albert O, Desdoits-Lethimonier C, Lesné L, Legrand A, Guillé F, Bensalah K, Dejucq-Rainsford N, Jégou B.  Hum Reprod.
  • International geographic correlation study of the prevalence of disorders of male reproductive health. Serrano T, Chevrier C, Multigner L, Cordier S, Jégou B.  Hum Reprod.
  • An essential role for insulin and IGF1 receptors in regulating Sertoli cells proliferation, testis size and FSH action in mice. Pitetti Jl, Calvel P, Zimmermann C, Conne B, Papaioannou Md, Aubry F, Cederroth C, Urner F, Fumel B, Crausaz M, Docquier M, Herrera Pl, Pralong F, Germond M, Guillou F, Jégou B, Nef S. Mol Endocrinol.
  • Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse. Chalmel F, Lardenois A, Georg I, Barrionuevo F, Demougin P, Jégou B, Scherer G, Primig M.  Andrology. 
  • Assuring safety without animal testing: The case for the human testis in vitro. Chapin RE, Boekelheide K, Cortvrindt R, Van Duursen Mb, Gant T, Jégou B, Marczylo E, Van Pelt Am, Post JN, Roelofs MJ, Schlatt S, Teerds KJ, Toppari J, Piersma AH.  Reprod Toxicol.


  • Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility. Chalmel F, Lardenois A, Evrard B, Mathieu R, Feig C, Demougin P, Gattiker A, Schulze W, Jégou B, Kirchhoff C, Primig M. Hum Reprod.
  • Human testis steroidogenesis is inhibited by phthalates. Desdoits-Lethimonier C, Albert O, Le Bizec B, Perdu E, Zalko D, Courant F, Lesné L, Guillé F, Dejucq-Rainsford N, Jégou B. Hum Reprod.
  • Impact of Short-Term HAART Initiated during the Chronic Stage or Shortly Post-Exposure on SIV Infection of Male Genital Organs. Moreau M, Le Tortorec A, Deleage C, Brown C, Denis H, Satie AP, Bourry O, Deureuddre-Bosquet N, Roques P, Le Grand R, Dejucq-Rainsford N.  PLoS One.
  • Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. Kristensen DM, Lesné L, Le Fol V, Desdoits-Lethimonier C, Dejucq-Rainsford N, Leffers H, Jégou B.  Int J Androl. 


  • Many putative endocrine disruptors inhibit prostaglandin synthesis. Kristensen DM, Skalkam ML, Audouze K, Lesné L, Desdoits-Lethimonier C, Frederiksen H, Brunak S, Skakkebæk NE, Jégou B, Hansen JB, Junker S, Leffers H.  Environ Health Perspect.
  • Loss of Dicer in Sertoli cells has a major impact on the testicular proteome of mice. Papaioannou MD, Lagarrigue M, Vejnar CE, Rolland AD, Kühne F, Aubry F, Schaad O, Fort A, Descombes P, Neerman-Arbez M, Guillou F, Zdobnov EM, Pineau C, Nef S.  Mol Cell Proteomics.
  • Revisiting rat spermatogenesis with MALDI imaging at 20-microm resolution. Lagarrigue M, Becker M, Lavigne R, Deininger SO, Walch A, Aubry F, Suckau D, Pineau C.  Mol Cell Proteomics
  • Analgesics during pregnancy and undescended testis. Philippat C, Giorgis-Allemand L, Chevrier C, Cordier S, Jégou B, Charles MA, Slama R.  Epidemiology.
  • The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes. Tanguy Y, Falluel-Morel A, Arthaud S, Boukhzar L, Manecka DL, Chagraoui A, Prevost G, Elias S, Dorval-Coiffec I, Lesage J, Vieau D, Lihrmann I, Jégou B, Anouar Y.  Endocrinology.
  • Human immunodeficiency virus infects human seminal vesicles in vitro and in vivo. Deleage C, Moreau M, Rioux-Leclercq N, Ruffault A, Jégou B, Dejucq-Rainsford N.  Am J Pathol
  • Excess type I interferon signaling in the mouse seminiferous tubules leads to germ cell loss and sterility. Satie AP, Mazaud-Guittot S, Seif I, Mahé D, He Z, Jouve G, Jégou B, Dejucq-Rainsford N.  J Biol Chem.
  • Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, Desdoits-Lethimonier C, Boberg J, Petersen JH, Toppari J, Jensen TK, Brunak S, Skakkebaek NE, Nellemann C, Main KM, Jégou B, Leffers H.  Hum Reprod.
  • The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages. Chi MN, Auriol J, Jégou B, Kontoyiannis DL, Turner JM, de Rooij DG, Morello D. Mol Biol Cell. 2
  • Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. Chauvigné F, Plummer S, Lesné L, Cravedi JP, Dejucq-Rainsford N, Fostier A, Jégou B.  PLoS One.
  • Dissecting the phthalate-induced Sertoli cell injury: the fragile balance of proteases and their inhibitors.Mazaud-Guittot S.  Biol Reprod.


  • Chlordecone exposure and risk of prostate cancer. Multigner L, Ndong JR, Giusti A, Romana M, Delacroix-Maillard H, Cordier S, Jégou B, Thome JP, Blanchet P. J Clin Oncol.
  • Testicular postgenomics: targeting the regulation of spermatogenesis. Calvel P, Rolland AD, Jégou B, Pineau C.  Philos Trans R Soc Lond B Biol Sci.
  • Vaginal exposure to cell-associated SIV results in rapid transmission of infection to macaques. Sallé B, Brochard P, Bourry O, Mannioui K, Andrieu T, Prevot S, Dejucq-Rainsford N, Bosquet N, Le Grand R.  Journal of Infectious Diseases.
  • The Highly conserved gonadotropin-releasing hormone-2 form acts as a melatonin-releasing factor in the pineal of a teleost fish, the european sea bass Dicentrarchus labrax. Servili A, Lethimonier C, Lareyre JJ, López-Olmeda JF, Sánchez-Vázquez FJ, Kah O, Muñoz-Cueto JA.  Endocrinology.
  • Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Kim KE,Yolamanova M, Zirafi O, Roan NR, Standker L, Forssmann WG, Burgener A, Dejucq-Rainsford N, Hahn BH, Shaw GM, Greene WC, Kirchhoff F, Muench J.  Retrovirology.
  • Proteome analysis and genome-wide regulatory motif prediction identify novel potentially sex-hormone regulated proteins in rat efferent ducts. Trépos-Pouplard M, Lardenois A, Staub C, Guitton N, Dorval-Coiffec I, Pineau C, Primig M, Jégou B.  Int J Androl.
  • HIV infection of the male genital tract- consequences for sexual transmission and reproduction. Le Tortorec A, Dejucq-Rainsford N.  Int J Androl. 
  • Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis. Mazaud-Guittot S, Meugnier E, Pesenti S, Wu X, Vidal H, Gow A, Le Magueresse-Battistoni B. Biol Reprod