Selection of publications - Team URGENT



  • Le Tortorec A., Matusali G., Mahé D., Aubry F., Mazaud-Guittot S., Houzet L., Dejucq-Rainsford N. (2020). From Ancient to Emerging Infections: The Odyssey of Viruses in the Male Genital Tract. Physiological Reviews. DOI: 10.1152/physrev.00021.2019 Réf. HAL: hal-02438417
  • Mahé D, Bourgeau S, Frouard J, Joguet G, Pasquier C, Bujan L, Dejucq-Rainsford N. (2020) Long-term Zika virus infection of non-sperm cells in the semen of infected men. Lancet Infectious Diseases. http://DOI: 10.1016/S1473-3099(20)30834-3
  • Mahé D, Matusali G, Deleage C, Alvarenga R, Satie A-P, Pagliuzza A , Bensalah K, Lavoué S, Jégou B, Chomont N, de França LR, Dejucq-Rainsford N. (2020) Potential for virus endogenization in humans through testicular germ cell infection: the case of HIV. Journal of Virology, Nov 23;94(24):e01145-20. DOI: 10.1128/JVI.01145-20
  • Lecluze E, Rolland AD, Filis P, Evrard B, Leverrier-Penna S, Maamar MB, Coiffec I, Lavoué V, Fowler PA, Mazaud-Guittot S, Jégou B, Chalmel F. (2020). Dynamics of the transcriptional landscape during human fetal testis and ovary development. Hum Reproduction, 35(5):1099-1119 p. DOI: Réf. HAL: hal-02464404v1
  • Entezami F, Samama M, Dejucq-Rainsford N*, Bujan L* (2020). SARS-CoV-2 and human reproduction: An open question. EClinicalMedicine. 25:100473. DOI: 10.1016/j.eclinm.2020.100473 .
  • Yefimova MG, Lefevre C, Bashamboo A, Eozenou C, Burel A, Lavault MT, Meunier AC, Pimentel C, Veau S, Neyroud AS, Jaillard S, Jégou B, Bourmeyster N, Ravel C. (2020). Granulosa cells provide elimination of apoptotic oocytes through unconventional autophagy-assisted phagocytosis. Human Reproduction. , deaa097. DOI:
  • Jaillard S., …, Belaud-Rotureau M.-A., ...Ravel C., .... (2020). Analysis of NR5A1 in 142 patients with premature ovarian insufficiency, diminished ovarian reserve, or unexplained infertility. Maturitas, vol 131, 78-86 p. DOI: Réf. HAL: hal-02399813


  • Rolland A. D., Evrard B., Darde T. A., Le Béguec C., Le Bras Y., Bensalah K., Lavoué S., Jost B., Primig M., Dejucq-Rainsford N., Chalmel F., Jégou B. (2019). RNA profiling of human testicular cells identifies syntenic lncRNAs associated with spermatogenesis. Human Reproduction, vol 34, n°7, 1278-1290 p. DOI: Réf. HAL: hal-02179
  • Nielsen J.*, Rolland A. D.*, Rajpert-De Meyts E.*, Janfelt C., Jørgensen A., Winge S., Kristensen D., Juul A., Chalmel F., Jégou B., Skakkebaek N. (2019). Characterisation and localisation of the endocannabinoid system components in the adult human testis. Scientific Reports, vol 9, n°1 DOI: Réf. HAL: hal-02441400
  • Kammerer-Jacquet S.-F., Brunot A., Lefort M., Bayat S., Peyronnet B., Verhoest G., Mathieu R., Lespagnol A., Mosser J., Laguerre B., Ravaud A., Bernhard J.-C., Dupuis F., Yacoub M., Belaud-Rotureau M.-A., Bensalah K., Rioux-Leclercq N. (2019). Metastatic Clear-cell Renal Cell Carcinoma With a Long-term Response to Sunitinib A Distinct Phenotype Independently Associated With Low PD-L1 Expression. Clinical Genitourinary Cancer, vol 17, n°3, 169-176.e1 p. DOI: Réf. HAL: hal-02076598
  • Darde T., Lecluze E., Lardenois A., Stévant I., Alary N., Tüttelmann F., Collin O., Nef S., Jégou B., Rolland A. D., Chalmel F. (2019). The ReproGenomics Viewer: a multi-omics and cross-species resource compatible with single-cell studies for the reproductive science community. Bioinformatics, vol 35, n°17, 3133-3139 p. DOI: Réf. HAL: hal-02015545
  • Buschiazzo A., Yefimova M., Bourmeyster N., Fautrel A., Burel A., Neyroud A.-S., Pimentel C., Jaillard S., Jégou B., Ravel C. (2019). Autophagie et spermatozoïde. Medecine Sciences M/s, vol 35, n°11, 852-858 p. DOI: Réf. HAL: hal-02441215


  • Matusali G., Houzet L., Satie A.-P., Mahé D., Aubry F., ..., Frouard J., Bourgeau S., …, Le Tortorec A., Dejucq-Rainsford N. (2018). Zika virus infects human testicular tissue and germ cells. Journal of Clinical Investigation, vol 128, n°10, 4697-4710 p. DOI: Réf. HAL:inserm-01868794
  • Houzet L., Pérez-Losada M., Matusali G., Deleage C., Dereuddre-Bosquet N., Satie A.-P., Aubry F., Becker E., Jégou B., Le Grand R., Keele B. F., Crandall K. A., Dejucq-Rainsford N. (2018). Seminal SIV in chronically-infected cynomolgus macaques is dominated by virus originating from multiple genital organs. Journal of Virology, vol 92, n°14, e00133-18 p. DOI: Réf. HAL: hal-01795804
  • Kristensen D. M., Desdoits-Lethimonier C., …, Lesne L., Mazaud-Guittot S., ...Jégou B. (2018). Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. Proceedings of the National Academy of Sciences of the United States of America, vol 115, n°4, E715-E724 p. DOI: Réf. HAL: hal-01710995
  • Leverrier-Penna S., Mitchell R., Becker E., Lecante L., Ben Maamar M., Homer N., Lavoue V., Kristensen D., Dejucq-Rainsford N., Jégou B., Mazaud-Guittot S. (2018). Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo. Human Reproduction, vol 33, n°3, 482-493 p. DOI: Réf. HAL: hal-01739999
  • Sèdes L., Desdoits-Lethimonier C., Rouaisnel B., Holota H., Thirouard L., Lesne L., Damon-Soubeyrand C., Martinot E., Saru J.-P., Mazaud-Guittot S., Caira F., Beaudoin C., Jégou B., Volle D. H. (2018). Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders. Stem Cell Reports, vol 11, n°4, 944-958 p. DOI: Réf. HAL: hal-01888869
  • Jaillard S., Tucker E. J., Akloul L., Beaumont M., Domin M., Pasquier L., Jouve G., Odent S., Belaud-Rotureau M.-A., Ravel C. (2018). 22q11.2 rearrangements found in women with low ovarian reserve and premature ovarian insufficiency. Journal of Human Genetics, vol 63, n°5, 691-698 p. DOI: Réf. HAL: hal-01780224
  • Lecluze E., Jégou B., Rolland A. D., Chalmel F. (2018). New transcriptomic tools to understand testis development and functions. Molecular and Cellular Endocrinology, vol 468, 47-59 p. DOI: Réf. HAL: hal-01864339
  • Darde T., Chalmel F., Svingen T. (2018). Exploiting advances in transcriptomics to improve on human-relevant toxicology. Current Opinion in Toxicology, vol 11-12, 43-50 p. DOI: Réf. HAL: hal-02161231
  • Frouard J., Le Tortorec A., Dejucq-Rainsford N. (2018). In vitro models for deciphering the mechanisms underlying the sexual transmission of viruses at the mucosal level. Virology, vol 515, 1-10 p. DOI: Réf. HAL: hal-01663650


  • Joguet G, Mansuy JM, Matusali G, Hamdi S, Walschaerts M, Pavili L, Guyomard S, Prisant N, Lamarre P, Dejucq-Rainsford N, Pasquier C, Bujan L. (2017). Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study. Lancet Infect Dis, vol 17, n°11, 1200-1208 p. DOI: Réf. HAL: hal-01647078
  • Gaudriault P., Mazaud-Guittot S., Lavoué V., Coiffec I., Lesné L., Dejucq-Rainsford N., Scholze M., Kortenkamp A., Jégou B. (2017). Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants. Environmental Health Perspectives, vol 125, n°8, 087004 p. DOI: Réf. HAL: hal-01579609
  • Desdoits-Lethimonier C., Lesné L., Gaudriault P., Zalko D., Antignac J.-P., Deceuninck Y., Platel C., Dejucq-Rainsford N., Mazaud-Guittot S., Jégou B. (2017). Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis. Human Reproduction, vol 32, n°7, 1465-1473 p. DOI: Réf. HAL: hal-01578582
  • Ben Maamar M., Lesné L., Hennig K., Desdoits-Lethimonier C., Kilcoyne K., Coiffec I., Rolland A. D., Chevrier C., Kristensen D., Lavoue V., Antignac J.-P., Le Bizec B., Dejucq-Rainsford N., Mitchell R., Mazaud-Guittot S., Jégou B. (2017). Ibuprofen results in alterations of human fetal testis development. Scientific Reports, vol 7, n°1, 44184 p. DOI: Réf. HAL: hal-01517095
  • Jégou B., Sankararaman S., Rolland A. D., Reich D., Chalmel F. (2017). Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry. Molecular Biology and Evolution, vol 34, n°8, 1974-1980 p. DOI: Réf. HAL: hal-01578587
  • Ravel C., Bourmeyster N., Becq F., Burel A., Lavault M. T., Pimentel C., Jouve G., Veau S., Sarandi S., Jégou B., Yefimova M. (2017). Heterozygous mutation of CFTR gene leads to activation of autophagy in Sertoli cells. Human Reproduction, vol 32, n°suppl_1, i159-i159 p. DOI: Réf. HAL: hal-01688588
  • Dugay F., Llamas-Gutierrez F., Gournay M., Médane S., Mazet F., Chiforeanu D. C., Becker E., Lamy R., Léna H., Rioux-Leclercq N., Belaud-Rotureau M.-A., Cabillic F. (2017). Clinicopathological characteristics of ROS1- and RET-rearranged NSCLC in caucasian patients. Data from a cohort of 713 non-squamous NSCLC lacking KRAS/EGFR/HER2/BRAF/PIK3CA/ALK alterations. Oncotarget, vol 8, n°32, 53336-53351 p. DOI: Réf. HAL: hal-01578586


  • Camus C., Matusali G., Bourry O., Mahé D., Aubry F., Bujan L., Pasquier C., Massip P., Ravel C., Zirafi O., Münch J., Roan N. R., Pineau C., Dejucq-Rainsford N. (2016). Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T cell infection. AIDS, vol 30, n°8, 1197-1208 p. DOI: Réf. HAL: hal-01274885
  • Kristensen D. M., Mazaud-Guittot S., Gaudriault P., Lesné L., Serrano T., Main K. M., Jégou B. (2016). Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects. Nature Reviews Endocrinology, vol 12, n°7, 381-393 p. DOI: Réf. HAL: hal-01359566
  • Holm J. B., Mazaud-Guittot S., ..., Chalmey C., ..., Jégou B., ... (2016). Intrauterine exposure to paracetamol and aniline impairs female reproductive development by reducing follicle reserves and fertility. Toxicological Sciences, vol 150, n°1, 178-189 p. DOI: Réf. HAL: hal-01259211
  • Sallou O., Duek P. D., Darde T. A., Collin O., Lane L., Chalmel F. (2016). PepPSy: a web server to prioritize gene products in experimental and biocuration workflows. Database - The journal of Biological Databases and Curation, vol 2016, baw070 p. DOI: Réf. HAL: hal-01342472
  • Jaillard S., Akloul L., Beaumont M., Hamdi-Rozé H., Dubourg C., Odent S., Duros S., Dejucq-Rainsford N., Belaud-Rotureau M.-A., Ravel C. (2016). Array-CGH diagnosis in ovarian failure: identification of new molecular actors for ovarian physiology. Journal of Ovarian Research, vol 9, n°1, 63 p. DOI: Réf. HAL: hal-01390979
  • Hao C., Gély-Pernot A., Kervarrec C., Boudjema M., Becker E., Khil P., Tevosian S., Jégou B., Smagulova F. (2016). Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice. Nucleic Acids Research, vol 44, 9784-9802 p. DOI: Réf. HAL: hal-01477213


  • Darde T. A., Sallou O., Becker E., Evrard B., Monjoeaud C., Le Bras Y., Jégou B., Collin O., Rolland A. D., Chalmel F. (2015). The ReproGenomics Viewer: an integrative cross-species toolbox for the reproductive science community. Nucleic Acids Research, vol 43, n°W1, 8 p. DOI: Réf. HAL: hal-01146120
  • Damouche A., ..., Dejucq-Rainsford N., Satie A.-P., ... (2015). Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection. PLoS Pathogens, vol 11, n°9, e1005153 p. DOI: Réf. HAL: hal-01207287
  • Matusali G., Dereuddre Bosquet N., Le Tortorec A., Moreau M., Satie A.-P., Mahé D., Roumaud P., Bourry O., Sylla N., Bernard-Stoecklin S., Pruvost A., Le Grand R., Dejucq-Rainsford N. (2015). Detection of Simian Immunodeficiency Virus in Semen, Urethra, and Male Reproductive Organs during Efficient Highly Active Antiretroviral Therapy. Journal of Virology, vol 89, n°11, 5772-5787 p. DOI: Réf. HAL: hal-01139816
  • Holm J. B., Chalmey C., Modick H., Jensen L. S., Dierkes G., Weiss T., Jensen B., Nørregård M. M., Borkowski K., Styrishave B., Koch H. M., Mazaud-Guittot S., Jégou B., Kristiansen K., Kristensen D. M. (2015). Aniline is rapidly converted into paracetamol impairing male reproductive development. Toxicological Sciences, vol 148, n°1, 288-298 p. DOI: Réf. HAL: hal-01187305
  • Houzet L., Deleage C., Satie A.-P., Merlande L., Mahé D., Dejucq-Rainsford N. (2015). A New Method for Rapid Screening of End-Point PCR Products: Application to Single Genome Amplified HIV and SIV Envelope Amplicons. PLoS ONE, vol 10, n°6, e0128188 p. DOI: Réf. HAL: hal-01163756
  • Ben Maamar M., Lesné L., Desdoits-Lethimonier C., Coiffec I., …, Dejucq-Rainsford N., Mazaud-Guittot S., Jégou B. (2015). An investigation of the endocrine-disruptive effects of bisphenol a in human and rat fetal testes. PLoS ONE, vol 10, n°2, e0117226 p. DOI: Réf. HAL: hal-01121759
  • Gély-Pernot A., Hao C., Becker E., Stuparevic I., Kervarrec C., Chalmel F., Primig M., Jégou B., Smagulova F. (2015). The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine. BMC Genomics, vol 16, n°1, 885 p. DOI: Réf. HAL: hal-01225493
  • Petit F., Kervarrec C., Jamin S., Smagulova F., Hao C., Becker E., Jégou B., Chalmel F., Primig M. (2015). Combining RNA and Protein Profiling Data with Network Interactions Identifies Genes associated with Spermatogenesis in Mouse and Human. Biology of Reproduction, vol 92, n°3, 1-18 p. DOI:​biolreprod.114.126250. Réf. HAL: hal-01122125
  • Chalmel F., Rolland A. D. (2015). Linking transcriptomics and proteomics in spermatogenesis. Reproduction, vol 150, n°5, R149-157 p. DOI: Réf. HAL: hal-01214005