Publications de l'équipe SMS

Pour consulter les publications sur le site PubMed, cliquez sur le nom du chercheur :
Dominique Lagadic-Gossmann
Eric Le Ferrec
Odile Sergent
Corinne Martin-Chouly
Normand Podechard
Lydie Sparfel

• Tête A, Gallais I, Imran M, Legoff L, Martin-Chouly C, Sparfel L, Bescher M, Sergent O, Podechard N, Lagadic-Gossmann D. MEHP/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement. Food Chem Toxicol. 2020 Oct 3;146:111798.
• van Meteren N, Lagadic-Gossmann D, Podechard N, Gobart D, Gallais I, Chevanne M, Collin A, Burel A, Dupont A, Rault L, Chevance S, Gauffre F, Le Ferrec E, Sergent O. Extracellular vesicles released by polycyclic aromatic hydrocarbons-treated hepatocytes trigger oxidative stress in recipient hepatocytes by delivering iron. Free Radic Biol Med. 2020 Aug 10;160:246-262.
• Le Goff M, Lagadic-Gossmann D, Latour R, Podechard N, Grova N, Gauffre F, Chevance S, Burel A, Appenzeller BMR, Ulmann L, Sergent O, Le Ferrec E. PAHs increase the production of extracellular vesicles both in vitro in endothelial cells and in vivo in urines from rats. Environ Pollut. 2019 Dec;255(Pt 1):113171.
• Le Goff M, Le Ferrec E, Mayer C, Mimouni V, Lagadic-Gossmann D, Schoefs B, Ulmann L. Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in human health and disease prevention. Biochimie. 2019 Sep 20;167:106-118. doi: 10.1016/j.biochi.2019.09.012. [Epub ahead of print]
• Lagadic-Gossmann D, Hardonnière K, Mograbi B, Sergent O, Huc L. Disturbances in H(+) dynamics during environmental carcinogenesis. Biochimie. 2019 Aug;163:171-183.
• van Meteren N, Lagadic-Gossmann D, Chevanne M, Gallais I, Gobart D, Burel A, Bucher S, Grova N, Fromenty B, Appenzeller BMR, Chevance S, Gauffre F, Le Ferrec E, Sergent O. Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor. Toxicol Sci. 2019 Jul 31. pii: kfz157. doi: 10.1093/toxsci/kfz157. [Epub ahead of print]
• Bucher S, Begriche K, Catheline D, Trak-Smayra V, Tiaho F, Coulouarn C, Pinon G, Lagadic-Gossmann D, Rioux V, Fromenty B. Moderate chronic ethanol consumption exerts beneficial effects on nonalcoholic fatty liver in mice fed a high-fat diet: possible role of higher formation of triglycerides enriched in monounsaturated fatty acids. Eur J Nutr. 2019 Jun 3. doi:10.1007/s00394-019-02017-1. [Epub ahead of print]
• Holme JA, Brinchmann BC, Le Ferrec E, Lagadic-Gossmann D, Øvrevik J. Combustion Particle-Induced Changes in Calcium Homeostasis: A Contributing Factor to Vascular Disease? Cardiovasc Toxicol. 2019 Jun;19(3):198-209
• Brinchmann BC, Le Ferrec E, Podechard N, Lagadic-Gossmann D, Holme JA, Øvrevik J. Organic chemicals from diesel exhaust particles affects intracellular calcium, inflammation and β-adrenoceptors in endothelial cells. Toxicol Lett. 2019 Mar;302:18-27.
• Nesseler N, Martin-Chouly C, Perrichet H, Ross JT, Rousseau C, Sinha P, Isslame S, Masseret E, Mallédant Y, Launey Y, Seguin P. Low Interleukin-10 Release after ex vivo Stimulation of Whole Blood is Associated with Persistent Organ Dysfunction in Sepsis: a Prospective Observational study. Anaesthesia Critical Care & Pain Medicine. 2019, 38(5):485-491.
• Luly FR*, Lévêque M*, Licursi V, Cimino G, Martin-Chouly C, theret N, Negri R, Cavinato L, Ascenzioni F, and Del Porto P. miR-146a is over-expressed and controls IL-6 production in Cystic Fibrosis macrophages. Sci Reports, 9(1):16259. *co-premiers auteurs
• Tête A, Gallais I, Imran M, Chevanne M, Liamin M, Sparfel L, Bucher S, Burel A, Podechard N, Appenzeller BMR, Fromenty B, Grova N, Sergent O, Lagadic-Gossmann D. Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide. Free Radic Biol Med. 2018 Dec;129:323-337.
• Brinchmann BC, Le Ferrec E, Bisson WH, Podechard N, Huitfeldt HS, Gallais I, Sergent O, Holme JA, Lagadic-Gossmann D, Øvrevik J. Evidence of selective activation of aryl hydrocarbon receptor nongenomic calcium signaling by pyrene. Biochem Pharmacol. 2018 Dec;158:1-12.
• Liamin M, Le Mentec H, Evrard B, Huc L, Chalmel F, Boutet-Robinet E, Le Ferrec E, Sparfel L. Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene. Int J Mol Sci. 2018 Nov 17;19(11).
• Bucher S, Le Guillou D, Allard J, Pinon G, Begriche K, Tête A, Sergent O, Lagadic-Gossmann D, Fromenty B. Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure. Oxid Med Cell Longev. 2018 Jul;2018:4396403.
• Imran M, Sergent O, Tête A, Gallais I, Chevanne M, Lagadic-Gossmann D, Podechard N. Membrane Remodeling as a Key Player of the Hepatotoxicity Induced by Co-Exposure to Benzo[a]pyrene and Ethanol of Obese Zebrafish Larvae. Biomolecules. 2018 May;8(2). pii: E26.
• Brinchmann BC, Skuland T, Rambøl MH, Szoke K, Brinchmann JE, Gutleb AC, Moschini E, Kubátová A, Kukowski K, Le Ferrec E, Lagadic-Gossmann D, Schwarze PE, Låg M, Refsnes M, Øvrevik J, Holme JA. Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s). Part Fibre Toxicol. 2018 May;15(1):21.
• Brinchmann BC, Le Ferrec E, Podechard N, Lagadic-Gossmann D, Shoji KF, Penna A, Kukowski K, Kubátová A, Holme JA, Øvrevik J. Lipophilic Chemicals from Diesel Exhaust Particles Trigger Calcium Response in Human Endothelial Cells via Aryl Hydrocarbon Receptor Non-Genomic Signalling. Int J Mol Sci. 2018 May;19(5). pii: E1429.
• Bucher S, Tête A, Podechard N, Liamin M, Le Guillou D, Chevanne M, Coulouarn C, Imran M, Gallais I, Fernier M, Hamdaoui Q, Robin MA, Sergent O, Fromenty B, Lagadic-Gossmann D. Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo. Sci Rep. 2018 Apr;8(1):5963.
• Le Ferrec E, Øvrevik J. G-protein coupled receptors (GPCR) and environmental exposure. Consequences for cell metabolism using the β-adrenoceptors as example. Current Opinion in Toxicology, 2018 Apr, 8:14-19.
• Bortoli S, Boutet-Robinet E, Lagadic-Gossmann D, Huc L. Nrf2 and AhR in metabolic reprogramming after contaminant exposure. Current Opinion in Toxicology, 2018 Apr, 8:34-41.
• Hardonnière K, Lagadic-Gossmann D. ATPase inhibitory factor 1 (IF1): a novel player in pollutant-related diseases? Current Opinion in Toxicology, 2018 Apr, 8:42-47.
• Lévêque M, Penna A, Le Trionnaire S, Belleguic C, Desrues B, Brinchault G, Jouneau S, Lagadic-Gossmann D, Martin-Chouly C. Phagocytosis depends on
  TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis. Sci Rep. 2018 Mar;8(1):4310.
• Liamin M, Boutet-Robinet E, Jamin EL, Fernier M, Khoury L, Kopp B, Le Ferrec E, Vignard J, Audebert M, Sparfel L. Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes. Biochem Pharmacol. 2017 Aug 1;137:113-124.
• Mayati A, Podechard N, Rineau M, Sparfel L, Lagadic-Gossmann D, Fardel O, Le Ferrec E. Benzo(a)pyrene triggers desensitization of β2-adrenergic pathway. Sci Rep. 2017 Jun 12;7(1):3262.
• Lévêque M, Simonin-Le Jeune K, Jouneau S, Moulis S, Desrues B, Belleguic C, Brinchault G, Le Trionnaire S, Gangneux JP, Dimanche-Boitrel MT, Martin-Chouly C. Soluble CD14 acts as a DAMP in human macrophages: origin and involvement in inflammatory cytokine/chemokine production. FASEB J. 2017 May;31(5):1891-1902.
• Hardonnière K, Huc L, Sergent O, Holme JA, Lagadic-Gossmann D. Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism. Semin Cancer Biol. 2017 Apr;43:49-65.
• Hardonnière K, Fernier M, Gallais I, Mograbi B, Podechard N, Le Ferrec E, Grova N, Appenzeller B, Burel A, Chevanne M, Sergent O, Huc L, Bortoli S,
  Lagadic-Gossmann D. Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype. Sci Rep. 2017 Mar;7(1):195.
• Podechard N, Chevanne M, Fernier M, Tête A, Collin A, Cassio D, Kah O, Lagadic-Gossmann D, Sergent O. Zebrafish larva as a reliable model for in vivo assessment of membrane remodeling involvement in the hepatotoxicity of chemical agents. J Appl Toxicol. 2017 Jun;37(6):732-746.

Mechanistic Toxicology: Metabolic Disruption in Environmental Diseases
Edited by Rodrigo Franco, Dominique Lagadic-Gossmann
Volume 8, Pages 1-110 (April 2018)