Dernières publications majeures de l'équipe TREC

Publications récentes de l'équipe " Transcription, environnement et cancer " dirigée par Farzad PAKDEL

2021
Jehanno C., Percevault F., Boujrad N., Le Goff P., Fontaine C., Arnal JF.; Michael Primig M., Pakdel F., Michel D., Métivier R., Flouriot G. (2021) Nuclear translocation of MRTFA in MCF7 breast cancer cells shifts ERα nuclear/genomic to extra-nuclear/non genomic actions. Molecular and Cellular Endocrinology 530, 111282.
Clusan L., Le Goff P., Flouriot G., Pakdel F. (2021) A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses. Int. J. Mol. Sci., 22(2), 756. (Review).
Pham T.H., Le Page Y., Percevault F., Ferriere F., Flouriot G., Pakdel F (2021) Apigenin, a Partial Antagonist of the Estrogen Receptor (ER), Inhibits ER-Positive Breast Cancer Cell Proliferation through Akt/FOXM1 Signaling. Int. J. Mol. Sci., 22, 470
2020
Pham TH, Lecomte S, Le Guevel R, Lardenois A, Evrard B, Chalmel F, Ferriere F, Balaguer P, Efstathiou T, Pakdel F (2020). Characterization of Glyceollins as Novel Aryl Hydrocarbon Receptor Ligands and Their Role in Cell Migration. International Journal of Molecular Sciences, 21 (4), pp.1368. ;10.3390/ijms21041368t;
Zahreddine R, Davezac M, Smirnova NF, Buscato M, Lhuillier E, Lupieri A, Solinhac R, Vinel A, Vessieres E, Henrion D, Renault MA, Gadeau AP, Flouriot G, Lenfant F, Laffargue M, Metivier R, Arnal JF, Fontaine C (2020) Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cell. Circ Res. Online ahead of print. PMID: 33012251
Fernández-Calero T, Davyt M, Perelmuter K, Chalar C, Bampi G, Persson H, Tosar JP, Hafstað V, Naya H, Rovira C, Bollati-Fogolín M, Ehrlich R, Flouriot G, Ignatova Z, Marín M (2020) Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells. Cancer Metab. 19;8:8.
Jehanno C, Fernandez-Calero T, Habauzit D, Avner S, Percevault F, Jullion E, Le Goff P, Coissieux MM, Muenst S, Marin M, Michel D, Métivier R, Flouriot G (2020) Nuclear accumulation of MKL1 in luminal breast cancer cells impairs genomic activity of ERα and is associated with endocrine resistance. Biochim Biophys Acta Gene Regul Mech. 1863(5):194507.
Flouriot G, Jehanno C, Le Page Y, Le Goff P, Boutin B, Michel D (2020) The Basal Level of Gene Expression Associated with Chromatin Loosening Shapes Waddington Landscapes and Controls Cell Differentiation. J Mol Biol. 27;432(7):2253-2270.
Fontaine C, Buscato M, Vinel A, Giton F, Raymond-Letron I, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Gourdy P, Milon A, Flouriot G, Ohlsson C, Lenfant F, Arnal JF (2020) The tissue-specific effects of different 17β-estradiol doses reveal the key sensitizing role of AF1 domain in ERα activity. Mol Cell Endocrinol. 505:110741.
Coumailleau P, Trempont S, Pellegrini E, Charlier TD (2020) Impacts of bisphenol A analogues on zebrafish post-embryonic brain. ] J Neuroendocrinol. 2020 Aug;32(8):
Pawluski JL, Kokras N, Charlier TD, Dalla C. (2020) Sex matters in neuroscience and neuropsychopharmacology. Eur J Neurosci. 52(1):2423-2428. Pawluski JL,
Paravatou R, Even A, Cobraiville G, Fillet M, Kokras N, Dalla C, Charlier TD (2020) Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. Neuropharmacology. 166:107950.
Vaillant C, Gueguen MM, Feat J, Charlier TD, Coumailleau P, Kah O, Brion F, Pellegrini E (2020) Neurodevelopmental effects of natural and synthetic ligands of estrogen and progesterone receptors in zebrafish eleutheroembryos. Gen Comp Endocrinol. 288:113345.
2019
Lecomte S, Demay F, Pham TH, Moulis S, Efstathiou T, Chalmel F, Pakdel F (2019) Deciphering the Molecular Mechanisms Sustaining the Estrogenic Activity of the Two Major Dietary Compounds Zearalenone and Apigenin in ER-Positive Breast Cancer Cell Lines. Nutrients, 11, 237.
Pham T.H., Lecomte S., Efstathiou T., Ferriere F., Pakdel F (2019) An Update on the Effects of Glyceollins on Human Health: Possible Anticancer Effects and Underlying Mechanisms. Nutrients, 11, 79.
2018
Pakdel F (2018) Molecular Pathways of Estrogen Receptor Action. Int J Mol Sci., 19, 2591
Hinfray N, Tebby C, Piccini B, Bourgine G, Aït-Aïssa S, Porcher JM, Pakdel F, Brion F (2018) Mixture Concentration-Response Modeling Reveals Antagonistic Effects of Estradiol and Genistein in Combination on Brain Aromatase Gene (cyp19a1b) in Zebrafish. Int J Mol Sci. 2018 Apr 1;19(4).
Cacialli P, D'angelo L, Kah O, Coumailleau P, Gueguen MM, Pellegrini E, Lucini C (2018)Neuronal expression of brain derived neurotrophic factor in the injured telencephalon of adult zebrafish. J Comp Neurol.1;526(4):569-582. doi: 10.1002/cne.24352. Epub 2017 Nov 26.
Gemmel M, Bögi E, Ragan C, Hazlett M, Dubovicky M, van den Hove DL, Oberlander TF, Charlier TD, Pawluski JL (2018) Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome. Neurosci Biobehav Rev. 85:102-116. doi: 10.1016/j.neubiorev.2017.04.023.
Gemmel M, Harmeyer D, Bögi E, Fillet M, Hill LA, Hammond GL, Charlier TD, Pawluski JL (2018). Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal behavior, in the rat dam. Behav Brain Res. 26;339:222-231. doi: 10.1016/j.bbr.2017.11.038
2017
Lecomte S, Habauzit D, Charlier T.D, Pakdel F. Emerging Estrogenic Pollutants in the Aquatic Environment and Breast Cancer. (2017) Genes 2017, 8, 229.
Lecomte S, Chalmel F, Ferriere F, Percevault F, Plu N, Saligaut C, Surel C, Le Long M, Efstathiou T, Pakdel F (2017) Glyceollins trigger anti-proliferative effects through estradiol-dependent and independent pathways in breast cancer cells. Cell Communication and Signaling, 15: 26.
Lecomte S, Demay F, Ferriere F, Pakdel F (2017) Phytochemicals targeting estrogen receptors: beneficial rather than adverse effects? Int J Mol Sci., 18, 1381.
Lecomte S, Le Long M, Bourgine G, Efstathiou T, Saligaut C, Pakdel F (2017) Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. Toxicol Appl Pharmacol, 325:61-70.
Habauzit D, Martin C, Kerdivel G, Pakdel F (2017) Rapid assessment of estrogenic compounds by CXCL-test illustrated by the screening of the UV-filter derivative Benzophenone (BP). Chemosphere, 173: 253-260.
Haas AJ, Le Page Y, Zhadobov M, Sauleau R, Le Drean Y, Saligaut C (2017) Effect of acute millimeter wave exposure on dopamine metabolism of NGF-treated PC12 cells. J Radiat Res, 58, 439-445.
2016
Jehanno C, Flouriot G, Le Goff P, Michel D (2016) A model of dynamic stability of H3K9me3 heterochromatin to explain the resistance to reprogramming of differentiated cells. Biochim. Biophys. Acta. Gene Regulatory Mechanisms , 1860, 184-195.
Chouchene L, Pellegrini E, Gueguen MM, Hinfray N, Brion F, Piccini B, Kah O, Saïd K, Messaoudi I, Pakdel F (2016) Inhibitory effect of Cadmium on estrogen signaling in zebrafish brain and protection by Zinc. J Appl Toxicol, 2016, 36: 863-871.
Jehanno C, Flouriot G, Nicol-Benoît F, Le Page Y, Le Goff P, Michel D (2016) Envisioning metastasis as a transdifferentiation phenomenon clarifies discordant results on cancer. Breast Dis., 36:47-59.
2014
Flouriot G., Huet G., Demay F., Pakdel F., Boujrad N., Michel D (2014) The actin/MKL1 signaling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone post-translational modifications. Biochem. J., 461:257-68.
Kerdivel G, Boudot A, Habauzit D, Percevault F, Demay F, Pakdel F, Flouriot G (2014) Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines. Mol Cell Endocrinol, 390:34-44.
Boudot A, Kerdivel G, Lecomte S, Flouriot G, Desille M, Godey F, Leveque J, Tas P, Le Dréan Y, Pakdel F (2014) COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration. BMC Cancer, 14:407.
Habauzit D., Ferrière F., Botherel N., Flouriot G., Pakdel F., Saligaut C (2014) Differentiation of PC12 cells expressing estrogen receptor alpha: a new bioassay for endocrine-disrupting chemicals evaluation. Chemosphere, 112, 240-247.