Liver is a major detoxification organ, dealing with and eliminating exogenic chemicals from the environment. These chemicals may interfere with hepatitis progression.
Our current work focuses on assessing the impact of pesticide exposure, such as chlordecone, on the development of chronic active hepatitis and liver fibrosis induced by alcohol or viruses. This work includes a comprehensive epidemiological study and an experimental study in mice.
Research axis 4, 2IFEF | Environmental co-factors in liver diseases
Secondary navigation
- The Institute
-
Research
- Research Fields
-
12 Research Teams
- Team O. Fardel | Xenobiotics and Barriers (XENOBAR)
-
Team M. Samson | Infection, Immunity and Environmental Factors in Liver (2IFEF)
- Research axis 1, 2IFEF | Cytokinic microenvironment during hepatitis
- Research axis 2, 2IFEF | Immune cells and liver sinusoidal endothelial cells (LSEC) in hepatitis
- Research axis 3, 2IFEF | Targeting cell death pathways in liver injuries
- Research axis 4, 2IFEF | Environmental co-factors in liver diseases
- Team members
- Publications
- Collaborations
-
Team D. Lagadic-Gossmann | Stress, Membrane and Signaling (SMS)
- Axis 1 | Analysis of the impact of contaminants on plasma membrane and related consequences in cell responses
- Axis 2 | Impact of environmental contaminants on intercellular communication via extracellular vesicles (EVs)
- Axis 3 | Analysis of the impact of contaminants on the pathologic progression of liver steatosis (fatty liver)
- "Membrane and Stress" Technical Core Facility
- Distinctions Team 3
- Major publications of SMS members
- Team 3 Members
- Team F. Smagulova | Chromatin, Epigenetics and Environment (CEE)
-
Team N. Théret, S. Langouët | Dynamics of Microenvironment, Contaminants and Cancer (DYMEC2)
- Axis 1 | Extracellular matrix remodeling
- Axis 2 | Mechanical constraints on hepatocyte phenotype and genotoxicity
- Axis 3 | Structural signature - SHG microscopy
- Axis 4 | Integrative biology and modelisation
- Team 5 [Dymec] Members
- Team 5 [Dymec] Major publications
- Team 5 [Dymec] Funding
- Team 5 [Dymec] Alumni
- Team M. Primig, G. Flouriot | DNA repair, RNA expression, Estrogen signaling and Mammary Carcinoma (DREAM)
- Team C. Pineau | Cellular and Molecular Actors of the Reproductive Function (COCOON)
-
Team N. Dejucq-Rainsford, F. Chalmel | Physiology and Physiopathology of the Uro-Genital Tract (URGENT)
- Axis 1 | Urogenital tract and viral exposures
- Axis 2 | Urogenital tract and environmental chemical exposures
- Axis 4 | Gonad differentiation and physiology
- Axis 3 | Urogenital tract and pharmaceutical chemical exposures
- Development of innovative tools
- Team 8 members
- Collaborations
- Publications
- Fundings
-
Team C. Chevrier, R. Garlantézec | Lifecourse Epidemiology and Exposure Science for Environmental Health (ELIXIR)
- Axis 1 | Environmental pre- and post-natal exposure, pregnancy, infant development
- Axis 2 | Environmental exposure, gene-environment interaction, prostate cancer
- Axis 3 | Environmental exposure and male and female fertility levels
- Axis 4 | Environmental exposure during pregnancy and infancy
- Members of the team directed by L.Multigner
- Team 9 Publications
- Team Y. Roquelaure | Epidemiology in Occupational Health and Ergonomics (ESTER)
- Team C. Proudhon – Circulating (Epi)markers ((E)MC)
- Équipe B. Laviolle | Variabilité et risques de l'exposition aux médicaments (VAGUE)
- One Innovation and R&D Platform
- Remarkable Initiatives
- IRSET's Publications
- Research Valuation
- Education
- Scientific activities
- International