Liver injury induced by acute or chronic viral hepatitis, alcoholic and non-alcoholic steatohepatitis (ASH and NASH), or drugs are associated with excessive hepatocyte cell death. This hepatocyte cell death response contributes to disease progression and to the development of liver fibrosis, cirrhosis and hepatocellular carcinoma. The understanding of what particular cell death is occurring is a key factor in elaborating protective strategies. Among extracellular signals, members of the Tumor Necrosis Factor (TNF) protein superfamily including TNF, Fas Ligand and TRAIL are the best characterized inducers of hepatocyte death.
Our team studies the death pathways involving RIPK1, RIPK3, MLKL, PARP1 or 2. These molecules will be studied in patients with acute or chronic hepatitis, and in animal models relevant to the further investigation of their role in hepatocyte cell death.
This project is approuved by the FRM in 2018
This distinction is a proof of excellence for an original and innovative project in medical research. The fondation pour la recherche médicale will fund the project for 3 years.