To overcome the lack of appropriate available solution, we are committed to the development and maintenance of several home-made programs for high-throughput data analysis and dissemination, including:
i) AMEN (Annotation, Mapping, Expression and Network), a tool for analysis and exploration of microarray data;
ii) GPSy (Gene Prioritization System), a gene ranking system allowing the prioritization of candidate genes from high-throughput approaches (transcriptomic, proteomic ...) for detailed functional analyzes;
iii) RGV (The ReproGenomics Viewer),a multi-species and inter-species work environment for the visualization, extraction and comparison of ultra-high throughput sequencing data in the field of reproductive biology;
iv) PepPSy (Peptide Prioritization System), a prioritization system based on gene expression to determine in which tissue (s) human proteins that have never been identified or highlighted must be sought;
v) TOXsIgN (TOXicogenomic sIgNature), a new public deposit area for toxicological signatures. This multi-species database provides a flexible and open environment that facilitates on-line submission and recovery of toxicological signatures submitted by the scientific community;
vi) GeneULike, a public repository for lists of biological entities (genes, transcripts, proteins) resulting from the analysis of high-throughput genomic data (under development).
Cellular and molecular tools
We are dedicated to the development of innovative culture systems and molecular biology methods, including: i) original cultures of adult human and fetal organs (testes, prostate, seminal vesicle, colon, exocervix, kidney ...); ii) a new method called LAMP (Long Amplicon Melt Profiling) for cost-effective and robust screening of large sets of PCR products.
We are an ANRS accredited platform for the ultra-sensitive detection of HIV / SIV in tissues associated with the identification of infected cell types by in situ hybridization and 4-color immunofluorescence.