In mammals, the oviduct and uterus are essential sites for female and male gamete transport, fertilization, implantation and maintenance of gestation. It is estimated that approximately 10-40% of embryos die before implantation. Therefore, the pathway of the embryo from the site of fertilization to the site of implantation is crucial, but not yet fully understood. Our project will therefore focus on the oviduct-embryo dialogue and the implantation process. Our aim is to identify in particular the post-translational modifications present on the surface of the embryo during its passage in the oviduct. We will also study the impact of oviductal architecture on embryo transport and development.
Relevant publications : PubMed