Axis 3, Team 4 | Impact of toxicants on genomic mutations

Study of genomic mutations

It is now well understood that exposure to toxicants during high replication activities in living organism could lead to genetic mutations (Carvalho, 2016).
The aim of our future researches is to investigate the mutations associated with certain toxicants and reveal the most common mutations. Recent data from the Timoun Mother-Child Cohort Study conducted in French West Indies show that prenatal exposure to CD at environmental levels may affect birth weight (Herve et al, 2016). We hypothesize that exposure to environmental factors will induce genomic mutations in certain error-prone regions. In this study, we will use the whole exome sequencing techniques and human umbilical cord samples exposed to chlordecone. We will reveal the mutations, which are associated with increased risk of cancer with the goal to discover a new biomarkers for diagnostic.
Conclusions: the results of our research are important for revealing the mechanisms of negative impacts of environmental factors on human health