Axis 3 | Gonad differentiation and physiology

The objective of our research is to better characterize the differentiation of gonadal cells and to decipher the complexity of the expression program, from fetal life to adulthood.


Research in reprotoxicology of our team in humans and rodents has demonstrated the inter-species specificity of the biological processes involved in gonadal development and functions. In order to better understand the deleterious effects of human viral and chemical exposure on human reproductive health, our research aims at modelling the program of differentiation of human gonadal cells from fetal life to adulthood by characterizing their expression program. In addition to transcriptomic approaches such as Affymetrix GeneChips, RNA-seq, DGE-seq, we analyze the transcriptome at the single cell level of developing uro-genital organs (single-cell RNA-seq, ChromiumTM system from 10x Genomics). This research is part of national (Inserm HuDeCa project) and international (european HuGoDeCa project) programs.

Contact: Frédéric Chalmel (Research Director Inserm), Antoine Rolland (Lecturer at Univ Rennes 1), Séverine Mazaud-Guittot (Senior scientist Inserm)