Axis 2 | Urogenital tract and environmental chemical exposures

There are increasing concerns about the impact of environmental substances on human reproductive health. We and others have indeed shown that a number of chemicals present in our everyday environment (phthalates, BPA…) modify the endocrine homeostasis of the human fetal and adult testes, which might in turn be involved in the rise in reproductive abnormalities reported in several countries (i.e. hypospadias, cryptorchidism, testis cancer…). Most of the environmental substances remain to be identified, classified and tested for their safety on human gonads.

  1. In silico predictive toxicology strategies
  2. Toxicological effects on the human testis of reprotoxic substances and emerging chemicals
  3. Combined effects of chemical mixtures

 

Axis 2 | Urogenital tract and environmental chemical exposures

In silico predictive toxicology strategies

The “omics” technologies represent extremely powerful tools to highlight molecular signatures with a high predictive potential. Our project is to identify, classify and prioritize novel endocrine disruptors and repro-toxicants by combining massive toxicogenomics data and bioinformatics approaches.

Contact: Frédéric Chalmel (CR1 Inserm)

Toxicological effects on the human testis of reprotoxic substances and emerging chemicals

The deleterious effects of environmental chemicals on the human testis are tested using in vitro (human cell line) and ex vivo (human fetal and adult testicular tissues) models in combination with classical toxicology (hormone production) and toxicogenomics approaches.

Contact: Bernard Jégou (DRE Inserm)

Combined effects of chemical mixtures

It is suspected that molecules with either recognized or yet unidentified endocrine disruptive activities could synergize and exert endocrine disrupting effects when in combination. One of our project aims at establishing the proof of principle that the “something from nothing” theory does exist in humans. To address this issue, a unique range of approaches are applied including computing modelization for the designing of the chemical mixtures, hormone production, in situ techniques and toxicogenomic approaches.

Contact: Bernard Jégou (DRE Inserm)