In silico predictive toxicology strategies
The “omics” technologies represent extremely powerful tools to highlight molecular signatures with a high predictive potential. Our project is to identify, classify and prioritize novel endocrine disruptors and repro-toxicants by combining massive toxicogenomics data and bioinformatics approaches.
Contact: Frédéric Chalmel (Research Director Inserm)
Effects of chemicals on the human testis and kidney during development and adulthood
We analyze at the cellular and molecular level the deleterious effects of environmental chemical compounds, medicinal products or drugs (e.g. cannabis) on the adults and developping testis. For this we combine ex vivo (organotypic culture ofhuman fetal and adult testicular tissues), in vitro (human cell line) and in vivo (cohorts, rodents) models with classical approaches of toxicology and toxicogenomics.
Contacts: Severine Mazaud-Guittot (Senior scientist Inserm) & Aurore Gely-Pernot (lecturer at EHESP)
Combined effects of chemical and biological agents
Our project is to explore the combined effect of chemicals (e.g. analgesics, cannabis) and infection with certain viruses (HIV, Zika virus) on the functions and development of human uro-genital organs (kidney, testis)
Contact: Nathalie Dejucq-Rainsford (Research Director Inserm)
