Axis 2, Team 6 | Environmental exposure on human health

Impact of chemical environmental exposure on human health

Impact of chemical environmental exposure on human health
The concept of "endocrine disrupter compounds" (EDCs) has emerged about twenty years ago and those chemicals represent a major challenge in environmental sciences and public health. 

Among EDCs, xenoestrogens represent the main categories of compounds with a large number of synthetic or natural chemicals present in the environment and diet. Some of these compounds are known to induce adverse effects on human and animal health, while some compounds may be beneficial and contribute to prevent disease development such as cancer and neurodegenerative diseases.
However, little is known about the molecular mechanisms of these molecules.
Our work is devoted to better understand their effects on cell proliferation/differentiation, cancer progression but also on brain development, focusing on neuronal networks underlying social interaction. A large array of techniques, from molecular biology and biochemistry, to histology and behavior are commonly used in several models (zebrafish, birds, rodents and humans).