Axis 1 | Differentiation of the Hypothalamic-Pituitary-Gonadal (HPG) axis

Project leader: Thierry Charlier

 

The communication between the brain, the pituitary gland and the gonads and placenta is a dynamic process that fluctuates throughout development but also in adulthood. The major players involved in this communication are sex steroids, including for example oestrogens and androgens. The specific mechanisms controlling the synthesis of these steroids by different organs, such as the gonads, placenta and brain, are not yet fully understood. Our work focuses in particular on sexual differences, on reproductive status (puberty, single and multiple motherhood,...) but also on anthropogenic factors such as endocrine disruptors.