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  1. NEW! Thesis Offer: PhD student position in HRMS-based exposomics at EHESP School of Public Health (France) / RECETEOX (Czech Republic)
  2. NEW! Junior Scientist | Innovative Biomarkers of Chronic Diseases (June 1, 2021)
  3. Post-doctoral position on SARS-CoV-2 and the male genital tract

NEW! Thesis Offer: PhD student position in HRMS-based exposomics at EHESP School of Public Health (France) / RECETEOX (Czech Republic)

The Environment and Health Research Laboratory (LERES) is the analytical platform of EHESP School of Public Health (Rennes, France). It is one of both analytical platforms of the Research Institute for Environmental and Occupational Health (IRSET Inserm UMR 1085), which is one of Europe's leading exposomics research centres performing cutting edge research in genomics, transcriptomics, analytical chemistry, toxicology, exposure science, epidemiology and risk assessment. The LERES facility is fully equipped with cutting edge mass spectrometry instruments (MS/MS and HRMS) to assess human exposure to inorganic and organic mixtures.

RECETOX is an independent department of Masaryk University’s Faculty of Science in Brno, Czech Republic, celebrating more than 35 years of academic and research excellence in the fields of environmental and health. Although it initially focused on the interactions among chemicals, environments, and biological systems, and their consequences on local, regional, and global levels, the Centre’s current, and long-term strategic vision is to become an international center of excellence, supporting research and education focused on unravelling the role of environmental factors in human health, aging, and wellbeing, developing innovative approaches to environmental and health protection, and tools for prevention, diagnostics, and intervention.

Description of the position
Chronic exposure of the general population to complex mixtures of chemicals is suspected of contributing to many adverse health outcomes such as non-communicable chronic diseases (NCDs) which are the major causes of premature death worldwide. Hence, deciphering the human chemical exposome (i.e. characterizing chemical mixtures and their transformation products accumulated in human biological matrices) and identifying the relevant chemical mixtures associated with NCDs would be a key step towards improving health and potentially reduce the overall burden of NCDs.
To this aim, innovative holistic methodologies methods are acutely needed to make a step change in human exposure assessment and capture the high diversity of exposures human is facing daily. Importantly, many NCDs could have their origins in utero (developmental origins of health and disease – DOHaD); it is therefore essential to focus on one of the most critical and vulnerable periods of development, i.e. the prenatal period.
The main objective of the PhD will be to develop a robust standardized methodology to apply suspect screening and non-targeted analyses based on high-resolution mass spectrometry (HRMS) to profile placenta samples from mother-child cohort studies. Profiling placenta using untargeted methods offers many advantages to monitor fetal exposure as many xenobiotics have been shown to accumulate over time in the placenta.
Initial work performed in both teams has ascertain that our HRMS-based chemical exposomics methods can detect low levels of chemicals and endogenous metabolites in human placentas. This PhD will benefit from a strong support network, including epidemiologists and biostatisticians at Irset UMR 1085, midwife at University Hospital of Rennes which have expertise in placenta, and international collaborators to use state of the art computational annotation workflow.

Qualifications
We seek a highly motivated and enthusiastic candidate with a master degree in analytical chemistry and initial expertise in the area of HRMS-based exposomics, metabolomics, or analytical chemistry. Essential skills for this job include experience in biological sample preparation techniques; practical expertise in liquid chromatographic methods and/or gas chromatography.

Location: LERES, EHESP School of Public Health (Rennes, France)

Contract: Short-term contract (3 years)

Closing date: 30 June 2021

Application
Please submit a single PDF containing your current curriculum vitae, contact information for three professional references, and a cover letter describing your interest in the position and how your qualifications meet the criteria outlined above to Dr Arthur David (arthur.david@ehesp.fr). Interested applicants can email Dr Arthur David for further information.

NEW! Junior Scientist | Innovative Biomarkers of Chronic Diseases (June 1, 2021)

In the context of personalized medicine to make treatment decisions about patients, IRSET is looking for a junior scientist willing to create his/her own team in the field of early and predictive biomarkers in chronic diseases. A promising field is the discovery of new biomarkers from biological fluids (e.g. blood, urine), such as circulating nucleic acids, extracellular vesicles (EVs), and/or metabolic biomarkers, allowing to follow the progression of chronic diseases (including cancers) and their response/resistance to treatments.
IRSET will provide the team with a dedicated research area (bench and office), and ensure access to the technological platforms and biological resources center on the site.
IRSET has recognized expertise in a range of chronic diseases affecting the liver, the lung, and the urogenital organs, as well as in hormone-dependent tumors of breast, ovary, and prostate. IRSET owns several biocollections of patient samples that will be made available to the selected candidate for him/her to carry out research.

Researcher profile: Established researcher (with more than 4 years research experience)

Required education level or diploma: PhD in molecular and cellular biology, pathophysiology

Required experience: 4 to 10 years

Fields / Key-words: early biomarkers, predictive biomarkers, biofluids, chronic diseases, cancer, hormone-dependent, urogenital, personalized medicine

Type of contract: Fixed-term contract (1 year renewable up to 3 years). Salary according to experience and to institutions’ grids

Envisaged start date: January 1, 2022

Application:
Applicants must send a detailed CV, including a list of published papers, and a cover letter detailing interest for the position to Dr Michel SAMSON, Director of IRSET | michel.samson@univ-rennes1.fr and contact@irset.org
Contact for further information (name, mail): Dr Michel SAMSON

Deadline for application: July 10, 2021

Post-doctoral position on SARS-CoV-2 and the male genital tract

Research project: The project comprises clinical (cohorts) and fundamental workpackages to investigate the infection of the male genital tract by SARS-CoV-2 and its consequences on endocrine and reproductive functions. We seek a highly motivated candidate to: (i) study infection of human testis and prostate in our unique ex vivo models and its functional consequences; (ii) analyze the interplay between SARS-CoV-2 and male hormones in vitro and in vivo. All the methodologies and tools are available in the team. This project is funded by Inserm-REACTing and the pharmaceutical company MSD.
Team: The project will be developed under the supervision of Dr Nathalie Dejucq-Rainsford, head of the team “Physiology and physiopathology of the male uro-genital tract” of the INSERM/ EHESP/University of Rennes U1085- Institute of Research on Health and Environment (IRSET). The project includes partners in Toulouse, Lyon, Paris and Buenos Aires involved in cohorts recruitments and biological assays.
Read the complete job profile here:

Contract: short-term contract
Starting date: 1st trimester 2021