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  1. Assistant-Professor in Biochemistry / Exposome
  2. Assistant-Professor in Cellular Biology and Immunology
  3. Post-doctoral position on SARS-CoV-2 and the male genital tract

Assistant-Professor in Biochemistry / Exposome

Research: Evaluation of human exposure to environmental contaminants (chemical exposome).
Technological advances in high-resolution mass spectrometry (HRMS), associated with the development of innovative bioinformatics tools, allows the characterization on large scale, without any a priori, the human exposure to chemical mixtures. These novel approaches based on HRMS, called “non-targeted”, provide a unique opportunity to capture the exposome (i.e. the totality of environmental exposures of an individual in a lifetime), and particularly the chemical exposome.
This new paradigm for exposure measurement offers new perspectives in the field of environmental health. The strategy of Irset, and more particularly the 3ERD team (Exposure Assessment and Epidemiological Research on Environment, Reproduction and Development) is to develop new research to better understand the links between environmental chemicals exposures and the occurrence of chronic diseases in large scale epidemiological studies. Irset aims, both at the University of Rennes and at the national (medical research) and European levels, to position this theme as a high priority.

Consequently, Irset offers a position of ATER (junior assistant professor) with excellent skills in analytical chemistry (and in particular in LC / GC-HRMS) and/or in bioinformatics (big data analysis) to join the 3ERD team which has already developed projects in this new field of research linked to the chemical exposome.

Successful candidate will have a strong background in analytical metabolomics/exposomics and/or bioinformatics for mining HRMS data.He/she will thus be responsible for developing new analytical and/or bioinformatics methods to conduct projects based on non-targeted HRMS analysis, on a large scale, of biological samples from epidemiological cohorts. These projects will aim to characterize, on a broad spectrum, exposures to mixtures of environmental chemicals and to study the existing associations between these exposures and health outcomes of interest to the host team. Strong interactions are expected with the epidemiologists from the host team but also with other Irset researchers with expertise in toxicology and "omics" sciences. The candidate must demonstrate very good communication skills in English in order to teach in English and to interact regularly with foreign researchers.

Teaching: Teaching general and analytical biochemistry as well as metabolism (French and English). Experience using omics techniques and integrated dimension of biochemistry. Research assessment of human exposure to environmental contaminants, especially environmental chemicals.

More information on the Euraxess website.

Contract: short-term contract
Starting date: September 1, 2021

Assistant-Professor in Cellular Biology and Immunology

Research: Inserm UMR 1085 Irset (Research Institute for Environmental and Occupational Health) studies the immune system in various pathophysiologies for which the regulation of the immune response is a determining factor in pulmonary pathologies (asthma, COPD, idiopathic pulmonary fibrosis), in autoimmune diseases such as scleroderma, in hepatic diseases (viral hepatitis, Non-Alcoholic Steato Hepatitis (NASH), parasitic hepatitis, fibrosis and cirrhosis), in inflammation of the urogenital tract, and in cancers of the liver and kidney.

Teaching: Teaching in cell biology to undergraduate students (L1, L2, L3 levels), teaching in immunology at L3 level (TD, TP) and Master’ degree; important teaching must be done in English and French.

More information on the Euraxess website.

Contract: short-term contract
Starting date: September 1, 2021

Post-doctoral position on SARS-CoV-2 and the male genital tract

Research project: The project comprises clinical (cohorts) and fundamental workpackages to investigate the infection of the male genital tract by SARS-CoV-2 and its consequences on endocrine and reproductive functions. We seek a highly motivated candidate to: (i) study infection of human testis and prostate in our unique ex vivo models and its functional consequences; (ii) analyze the interplay between SARS-CoV-2 and male hormones in vitro and in vivo. All the methodologies and tools are available in the team. This project is funded by Inserm-REACTing and the pharmaceutical company MSD.
Team: The project will be developed under the supervision of Dr Nathalie Dejucq-Rainsford, head of the team “Physiology and physiopathology of the male uro-genital tract” of the INSERM/ EHESP/University of Rennes U1085- Institute of Research on Health and Environment (IRSET). The project includes partners in Toulouse, Lyon, Paris and Buenos Aires involved in cohorts recruitments and biological assays.
Read the complete job profile here:

Contract: short-term contract
Starting date: 1st trimester 2021