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NEW! Thesis Offer: PhD student position in HRMS-based exposomics at EHESP School of Public Health (France) / RECETEOX (Czech Republic)

The Environment and Health Research Laboratory (LERES) is the analytical platform of EHESP School of Public Health (Rennes, France). It is one of both analytical platforms of the Research Institute for Environmental and Occupational Health (IRSET Inserm UMR 1085), which is one of Europe's leading exposomics research centres performing cutting edge research in genomics, transcriptomics, analytical chemistry, toxicology, exposure science, epidemiology and risk assessment. The LERES facility is fully equipped with cutting edge mass spectrometry instruments (MS/MS and HRMS) to assess human exposure to inorganic and organic mixtures.

RECETOX is an independent department of Masaryk University’s Faculty of Science in Brno, Czech Republic, celebrating more than 35 years of academic and research excellence in the fields of environmental and health. Although it initially focused on the interactions among chemicals, environments, and biological systems, and their consequences on local, regional, and global levels, the Centre’s current, and long-term strategic vision is to become an international center of excellence, supporting research and education focused on unravelling the role of environmental factors in human health, aging, and wellbeing, developing innovative approaches to environmental and health protection, and tools for prevention, diagnostics, and intervention.

Description of the position
Chronic exposure of the general population to complex mixtures of chemicals is suspected of contributing to many adverse health outcomes such as non-communicable chronic diseases (NCDs) which are the major causes of premature death worldwide. Hence, deciphering the human chemical exposome (i.e. characterizing chemical mixtures and their transformation products accumulated in human biological matrices) and identifying the relevant chemical mixtures associated with NCDs would be a key step towards improving health and potentially reduce the overall burden of NCDs.
To this aim, innovative holistic methodologies methods are acutely needed to make a step change in human exposure assessment and capture the high diversity of exposures human is facing daily. Importantly, many NCDs could have their origins in utero (developmental origins of health and disease – DOHaD); it is therefore essential to focus on one of the most critical and vulnerable periods of development, i.e. the prenatal period.
The main objective of the PhD will be to develop a robust standardized methodology to apply suspect screening and non-targeted analyses based on high-resolution mass spectrometry (HRMS) to profile placenta samples from mother-child cohort studies. Profiling placenta using untargeted methods offers many advantages to monitor fetal exposure as many xenobiotics have been shown to accumulate over time in the placenta.
Initial work performed in both teams has ascertain that our HRMS-based chemical exposomics methods can detect low levels of chemicals and endogenous metabolites in human placentas. This PhD will benefit from a strong support network, including epidemiologists and biostatisticians at Irset UMR 1085, midwife at University Hospital of Rennes which have expertise in placenta, and international collaborators to use state of the art computational annotation workflow.

Qualifications
We seek a highly motivated and enthusiastic candidate with a master degree in analytical chemistry and initial expertise in the area of HRMS-based exposomics, metabolomics, or analytical chemistry. Essential skills for this job include experience in biological sample preparation techniques; practical expertise in liquid chromatographic methods and/or gas chromatography.

Location: LERES, EHESP School of Public Health (Rennes, France)

Contract: Short-term contract (3 years)

Closing date: 31 October 2021

Application
Please submit a single PDF containing your current curriculum vitae, contact information for three professional references, and a cover letter describing your interest in the position and how your qualifications meet the criteria outlined above to Dr Arthur David (arthur [dot] davidatehesp [dot] fr). Interested applicants can email Dr Arthur David for further information.

NEW! Post-Doctoral Position - Innate Immune Mechanisms Associated With Viral Persistence In The Human Testis

We offer a 30-month postdoctoral position in a multidisciplinary environment that will provide opportunities for impactful research. The project will build on state-of-the-art methodology including single-cell RNA seq combined with unique human tissue culture, and you will have access to newly generated genomic data. Since this is a collaborative project, you will interact with several world-class researchers at Pasteur Institute in Paris and Geneva University. You will enjoy a large degree of autonomy to organize your work. The institute will support the career development of candidate who will demonstrate their ability to successfully lead research.

Read the complete job profile here:

POST-DOCTORAL POSITION – INNATE IMMUNE MECHANISMS ASSOCIATED WITH VIRAL PERSISTENCE IN THE HUMAN TESTIS - (706.27 Ko)