Environmental factors and toxicants interfere with natural cellular processes. There is a rapidly growing body of evidence that environmental toxicants negatively impact human health. In our research we study the effects of environmental factors such as pesticides, chemical toxicants and drugs on meiosis, which is a key step in sexual reproduction. Specifically, we are interested in the effects of the toxicants on epigenetic mechanisms controlling germ cell development. We are also working on mechanisms governing transgenerational inheritance and how they are affected by environmental factors. In our research we are using inbred and outbred mouse model systems and high-throughput sequencing techniques.