Open positions

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PhD position on Zika virus – Inserm U1085 (Rennes, France) and Pasteur Institute – Chinese Academy of Sciences (Shanghai, China)

Available for a period of 3 years with 1st and 3rd year at INSERM U1085-IRSET, University of Rennes (France), and 2d year at the Pasteur Institute of Shanghai – Chinese Academy of Sciences (IPS-CAS China). Funding: Rennes I University/IPS CAS.

Starting date: October 2017.

Project

Zika virus (ZIKV) is an emerging arbovirus responsible in pregnant women for a devastating congenital malformation called microcephaly. The virus is primarily transmitted by mosquitoes but several cases of sexual transmission have been reported outside of the epidemic zone. The virus can persist in semen for months after its clearance from the blood, and mouse studies indicate a tropism of ZIKV for the testis and epididymis. The major aim of the project is to determine the cellular and molecular events underlying ZIKV tropism for the human testis. The successful candidate will perform original research using organotypic culture of human tissue, immunofluorescence and in situ hybridization, quantitative PCR, flow cytometry, confocal microscopy, generation of KO cell line using the CRIPSR/Cas9 technology, siRNA/shRNA, chimeric viruses and mouse model. The project is part of a European consortium on Zika virus research.

Your Profile

– Master 2 degree in Virology or Cellular and Molecular Biology, obtained in 2017. For your application to be considered, you need to be ranked among the top third of your Master 2.

  • Skills and knowledge in cell culture, in primary cell/organ culture, molecular biology and virology are necessary. The candidate should master at least part of the techniques mentioned above. Previous experience in a security lab L2/L3 will be a bonus.
  • International mobility required (2 years in France, and an intermediate year in China). The successful applicant must be fluent in oral and written English.
  • We seek a highly motivated and talented PhD student. The candidate should be creative and capable of developing a competitive research project while working in autonomy under the supervision of a team leader.

How to apply

Send your CV with a motivation letter and the contact details of two referees electronically as one PDF-file to Drs Nathalie Dejucq-Rainsford and Dimitri Lavillette (dlaville@ips.ac.cn).

Application deadline for pre-selection is 15 May 2017.

The selected candidates will hold a competitive oral presentation in front of the Rennes University doctoral school (VAS) jury on 27-28 June 2017.